Department of Biochemistry
4-403 BSB
Iowa City, IA 52242-1109 USA phone: 877-846-8569
or 319-335-7932
fax: (319) 335-9570
biochem@uiowa.edu
Department of Biochemistry
Professor of Biochemistry, PhD
51 Newton Rd
Department of Biochemistry
Iowa City, IA 52242
Predoctoral, Doctoral, and Postdoctoral Education
1977 University of Illinois, Biology and Chemistry, BS
1979 Princeton University, Princeton, NJ, Biology, MA
1984 Princeton University, Princeton, NJ, Biology, PhD
Postdoctoral Training
1984-1988 University of Chicago, Dept. Molecular Genetics and Cell Biology
Research Interests
Molecular genetics and cell biology
Epidermal adhesion molecules
Epidermal proteins
Blistering diseases of the skin
Academic Appointments
1988 Instructor, Dept. Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL
1989-1994 Asst. Prof. Depts Dermatology and Biochemistry, Medical College of Wisconsin, Milwaukee, WI
1994-1999 Assoc. Prof. Depts Dermatology and Biochemistry, Medical College of Wisconsin, Milwaukee, WI
1999-2007 Professor, Depts Dermatology and Biochemistry, Medical College of Wisconsin, Milwaukee, WI
2006-2007 Director of Research, Dept. Dermatology, Medical College of Wisconsin, Milwaukee, WI
2007-- Professor & Dir. of Research, Dept. Dermatology, University of Iowa, Iowa City, IA
2008-- Professor, Dept. Biochemistry, University of Iowa, Iowa City, IA
Recent Publications
Lin, M-S., C.L. Fu, M. Olague-Marchan, M.K. Hacker, D. Zillikens, G.J. Giudice, and J.A. Fairley. Autoimmune responses in patients with linear IgA bullous dermatosis: Both autoantibodies and T lymphocytes recognize the NC16A domain of the BP180 molecule. Clin. Immunol. 102:310-319, 2002.
Chen, R., J.A. Fairley, M-L. Zhao, G.J. Giudice, D. Zillikens, L.A. Diaz, and Z. Liu. Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: Macrophage-mediated neutrophil infiltration depends on mast cell activation. J. Immunol. 169:3987-3992, 2002.
Warren, S.J.P., L.A. Arteaga, E.A. Rivitti, V. Aoki, G. Hans-Filho, B.F. Qaqish, M-S. Lin, G.J. Giudice, and L.A. Diaz. The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus, J. Invest. Dermatol. 120:104-108, 2003.
Dimson O.G., G.J. Giudice, C-L. Fu, F. Van den Bergh, S.J. Warren, M.M. Janson and J.A. Fairley. Identification of a potential effector function for IgE autoantibodies in the organ-specific autoimmune disease bullous pemphigoid. J. Invest. Dermatol. 120:784-788, 2003.
Hacker-Foegen, M., D. Zillikens, G.J. Giudice, M-S. Lin. T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis. Clin. Immunol. 113:179-186, 2004.
Fairley, J.A., D.T. Woodley, M.Chen, G.J. Giudice, M.S. Lin. A patient with bullous pemphigoid and epidermolysis bullosa acquisita: An example of intermolecular epitope spreading. J. Am. Acad. Dermatol. 51:117-121, 2004.
Fairley, J.A., C.L. Fu, G.J. Giudice. Mapping the binding sites of anti-BP180 IgE autoantibodies in bullous pemphigoid. J. Invest. Dermatol. 125:467-472, 2005.
Fu, C-L., G.J. Giudice, F. Van den Bergh. Protein structural analysis of BP180 mutant isoforms linked to non-Herlitz junctional epidermolysis bullosa. J. Invest. Dermatol. 126:232-234, 2006.
Van den Bergh, F., C-L. Fu, M. Olague-Marchan, G.J. Giudice. The NC16A domain of collagen XVII plays a role in triple helix assembly and stability. Biochem. Biophys. Res. Comm. 350:1032-1037, 2006.
Fairley, J.A., C.T. Burnett, C-L. Fu, D.L. Larson, M.G. Fleming, G.J. Giudice. A pathogenic role for IgE in autoimmunity: Bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice. J. Invest. Dermatol., 2007 Nov;127(11):2605-11.
Affiliations
Biochemistry DepartmentComments or questions about our Web site? Contact the Webmaster.