Department of Biochemistry
4-403 BSB
Iowa City, IA 52242-1109 USA phone: 877-846-8569
or 319-335-7932
fax: (319) 335-9570
biochem@uiowa.edu
Department of Biochemistry
Assistant Professor, Molecular Pathology
Director, Molecular Oncology Testing
M.D., Ph.D.
51 Newton Rd
Department of Biochemistry
Iowa City, IA 52242
Research Interests
My clinical responsibility is development and evaluation of molecular tests relating to oncology. My laboratory does work in three main areas.
- We use the tools of biochemistry and genetics to understand how histone methyltransferases are regulated and targeted.
- We are mapping the contribution of individual histone methyltransferases to the differentiation of hematopoietic cell lineages.
- We screen tumor samples for mutations in histone methyltransferases to extend our understanding of the role of these enzymes in human malignancies.
Recent Publications
E Nedea, D Nalbant, D Xia, NT Theoharis, B Suter, CJ Richardson, K Tatchell, T Kislinger, JF Greenblatt, and PL Nagy. The Glc7 Phosphatase Subunit of the Cleavage and Polyadenylation Factor Is Essential for Transcription Termination on snoRNA Genes. Molecular Cell 29, 577-587, March 14, 2008.
Nagy PL, Griesenbeck J, Kornberg RD, Cleary ML. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc. Natl. Acad. Sci. USA. 99(1): 90-4. 2002.
Nagy PL, Cleary ML, Brown PO, Lieb JD. Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin. Proc. Natl. Acad. Sci. USA. 100(11): 6364-9. 2003
Nagy PL, Marolewsky A, Benkovic S, Zalkin H. Formyltetrahydrofolate Hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli. J. Bacteriol. 177:1292-98. 1995.
Affiliations
Biochemistry DepartmentPathology Department
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